3-Fluoro-4-methylphenylmagnesium bromide
3-Fluoro-4-methylphenylmagnesium bromide
CAS: 185077-02-5
Molecular Formula: C7H6BrFMg
3-Fluoro-4-methylphenylmagnesium bromide - Names and Identifiers
3-Fluoro-4-methylphenylmagnesium bromide - Physico-chemical Properties
| Molecular Formula | C7H6BrFMg |
| Molar Mass | 213.3299432 |
| Density | 0.953g/mLat 25°C |
| Boling Point | 65°C |
| Flash Point | 1°F |
| Water Solubility | Reacts with water. |
| Storage Condition | 2-8°C |
| Sensitive | Air & Moisture Sensitive |
3-Fluoro-4-methylphenylmagnesium bromide - Risk and Safety
| Risk Codes | R11 - Highly Flammable R14/15 - R19 - May form explosive peroxides R34 - Causes burns R40 - Limited evidence of a carcinogenic effect R36/37 - Irritating to eyes and respiratory system. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S33 - Take precautionary measures against static discharges. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S43 - In case of fire use ... (there follows the type of fire-fighting equipment to be used.) S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 2924 3/PG 2 |
| WGK Germany | 1 |
| HS Code | 29310099 |
| Hazard Class | 3 |
3-Fluoro-4-methylphenylmagnesium bromide - Introduction
bromide (bromide) is an organic magnesium reagent, often referred to as FMeMgBr. It contains a 3-fluoro-4-methylphenyl group and a bromide ion.
By its nature, FMeMgBr is a colorless to light yellow liquid. It has good solubility and can be dissolved in inert solvents (such as ether, tetrahydrofuran) to generate a strong alkaline magnesium organic solution. FMeMgBr are susceptible to moisture and caking and need to be kept dry during storage.
FMeMgBr are commonly used as reaction intermediates and can be used in the synthesis of organic compounds. It can undergo a substitution reaction, introducing its 3-fluoro-4-methylphenyl group into other compounds. At the same time, FMeMgBr can also react with some electrophilic reagents, such as acid chloride, ketone, aldehyde, etc., to generate corresponding organic compounds such as alcohol, ketone, etc.
A common method for preparing FMeMgBr is by reacting magnesium with 3-fluoro-4-methylbromobenzene. The reaction is usually carried out in an inert solvent such as diethyl ether while controlling the temperature and reaction conditions to avoid side reactions or violent reactions.
Regarding safety information, FMeMgBr is an organometallic reagent with high reactivity and corrosiveness. Safety measures such as wearing appropriate protective gloves, glasses and laboratory clothing are required during operation. At the same time, avoid contact with air, moisture and other oxidants to avoid dangerous reactions. During storage and handling, it should be kept in a dry, well-ventilated place, and stored in isolation from other chemicals, avoiding fire and high temperature. In the use and handling of reagents, should follow the appropriate safety procedures.
By its nature, FMeMgBr is a colorless to light yellow liquid. It has good solubility and can be dissolved in inert solvents (such as ether, tetrahydrofuran) to generate a strong alkaline magnesium organic solution. FMeMgBr are susceptible to moisture and caking and need to be kept dry during storage.
FMeMgBr are commonly used as reaction intermediates and can be used in the synthesis of organic compounds. It can undergo a substitution reaction, introducing its 3-fluoro-4-methylphenyl group into other compounds. At the same time, FMeMgBr can also react with some electrophilic reagents, such as acid chloride, ketone, aldehyde, etc., to generate corresponding organic compounds such as alcohol, ketone, etc.
A common method for preparing FMeMgBr is by reacting magnesium with 3-fluoro-4-methylbromobenzene. The reaction is usually carried out in an inert solvent such as diethyl ether while controlling the temperature and reaction conditions to avoid side reactions or violent reactions.
Regarding safety information, FMeMgBr is an organometallic reagent with high reactivity and corrosiveness. Safety measures such as wearing appropriate protective gloves, glasses and laboratory clothing are required during operation. At the same time, avoid contact with air, moisture and other oxidants to avoid dangerous reactions. During storage and handling, it should be kept in a dry, well-ventilated place, and stored in isolation from other chemicals, avoiding fire and high temperature. In the use and handling of reagents, should follow the appropriate safety procedures.
Last Update：2024-04-09 21:11:58
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